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DiagBox V5.29 is the latest update for DiagBox and is used to diagnose Peugeot, Citroen and.Integrin α6β1 functions in the pathogenesis of ovarian cancer.
Integrins are transmembrane receptors of the extracellular matrix that function to mediate cell-to-cell and cell-to-extracellular matrix adhesion. Integrin α6β1 is expressed in multiple tissues and plays an important role in the pathogenesis of cancer, mainly in the development of some malignant tumors. The mechanism of cancer cell invasion is associated with the formation of multicellular tumor spheroids (MCTS) by cancer cell aggregation. To test whether integrin α6β1 can influence MCTS formation and tumor invasion, we have developed a stably transfected epithelial cell line expressing high levels of integrin α6β1. MCTS formation and invasive properties of integrin α6β1-expressing ovarian cancer cells were studied. We found that overexpression of integrin α6β1 increased MCTS formation and enhanced the invasive ability of the OVCA429 and OVCA 429Coas cell lines. The expression of matrix metalloproteinase (MMP)-2 and -9 was also increased, especially MMP-9, which is known to play an important role in ovarian cancer cell invasion. The expression level of plasminogen activator inhibitor-1 was found to be decreased in integrin α6β1-expressing OVCA429 cells and may contribute to increased MMP-9 activity. These results demonstrated that integrin α6β1 may function to promote tumor growth and invasion in ovarian cancer by regulating the expression of MMP-9, PAI-1, and MCTS formation.Q:
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