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Counter-Strike 1.6 cheats password counter strike. Counter Strike 1.6 Free Download Full Version PC Game setup in single direct link for windows. Free Counter Strike Download Free Download. Counter Strike Source trainer for 1.6.1 Counter.1. Field of the Invention
This invention relates to a compound that inhibits blood coagulation in a mammal, in particular a human, comprising the compound of the general formula: ##STR1## wherein X is oxygen or sulfur and R is 1-phenyl-3-(4-sulfamoylphenyl)-1-propanone, the optical isomers thereof, pharmaceutically acceptable acid addition salts of the optical isomers and hydrates of the same. This invention further relates to a pharmaceutical composition comprising a therapeutically effective amount of the compound as defined above and a pharmaceutically acceptable carrier. This invention also relates to a method of inhibiting blood coagulation comprising administering to a mammal in need of such treatment a therapeutically effective amount of the compound as defined above. This invention also relates to the use of the compound as defined above, the optical isomers thereof, the pharmaceutically acceptable acid addition salts and hydrates thereof, in the manufacture of a medicament for the treatment of blood coagulation disorders. This invention also relates to a method for reducing or eliminating thrombus formation in a mammal in need of such treatment comprising administering to the mammal in need of such treatment a therapeutically effective amount of the compound as defined above.
2. Description of the Prior Art
A variety of substances are known to those skilled in the medicinal arts which have utility in the prophylaxis and treatment of thromboembolic disorders. For example, U.S. Pat. No. 4,557,864 issued Dec. 10, 1985, teaches the use of nafamostat (U-731 A), which is a synthetic protease inhibitor of the formula: ##STR2## which is useful in treating, preventing and/or controlling thromboembolic disorders.
On the other hand, the anticoagulant properties of sulfamoylphenyl compounds have been reported by H. Oikawa et al., Yakugaku Zasshi, 76, pp. 1031-1040 (1956) and U.S. Pat. No. 4,124,576 issued Nov. 7, 1978. The references do not indicate or suggest the specific sulfam
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