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Softbye v11 11hg full (720p/1080p)The following relates generally to wireless communication, and more specifically to discovery methods of user equipments (UEs). Wireless communications systems are widely deployed to provide various types of communication content such as voice, video, packet data, messaging, broadcast, and so on. These systems may be capable of supporting communication with multiple UEs by sharing the available system resources (e.g., time, frequency, and power). Examples of such multiple-access systems include code division multiple access (CDMA) systems, time division multiple access (TDMA) systems, frequency division multiple access (FDMA) systems, and orthogonal frequency division multiple access (OFDMA) systems, (e.g., a Long Term Evolution (LTE) system). A UE may transmit a discovery signal at a power level that may be used to monitor broadcast signals and detect whether another UE is present in the vicinity. This discovery signal may provide UEs with information (e.g., identity, time synchronization information, and the like) that is needed for successful initial access of the UE to the network.Identification of a common haplotype of the endothelin type A receptor gene and reduced effectiveness of dihydropyridine calcium channel blocker in a dyslipidemic cohort: the Korean Heart Study. To identify the genetic determinants of dyslipidemia in Korean population, we analyzed the relationship between the endothelin type A receptor (ETA) gene in 520 subjects from the Korean Heart Study. The C1100T polymorphism, which is a missense polymorphism leading to a threonine to alanine amino acid substitution at codon 350 in the third intracellular domain, was identified. The frequency of the ETA 1100 allele and the 1100 variant were 0.542 and 0.026, respectively. The TT homozygote, which caused a completely loss of the ETA-specific binding sites of the G protein, was less frequently found in dyslipidemic subjects compared with the subjects with normolipidemia (odds ratio=0.155, 95% CI=0.036-0.662, P=0.012). However, the frequency of the TT genotype did not differ between those with type 2 diabetes mellitus (T2DM) and those without T2DM. The haplotype analysis of the ETA gene revealed that the frequency of the TC haplotype, composed of the ETA 1100 allele and the T2379C polymorphism, was significantly increased in dyslipidemic subjects compared with normolipidemic subjects (P=0.00029). When the dyslipidemia was stratified by fasting triglyceride or total cholesterol concentrations, this trend did not reach statistical significance. Compared with hypertriglyceridemic subjects, normolipidemic subjects with the TC haplotype had a significantly higher frequency of total cholesterol >240 mg/dL and triglyceride >200 mg/dL (all P<0.05). The subjects with the TC haplotype showed an approximately half of the effect of the T2379C polymorphism on the threshold of triglyceride concentration (P=0.007). These results suggest that the T2379C polymorphism in the ETA gene may play a role in the pathogenesis of hypertriglyceridemia in the Korean population.
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