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Heat shock factor (HSF) is a ubiquitous transcriptional factor which, besides increasing the transcription of heat shock proteins (HSPs), is involved in the regulation of cell metabolism, proliferation and the immune response. Our study evaluates the expression of HSF-1 in peripheral blood mononuclear cells (PBMCs) and the correlation between HSF-1 and disease activity in multiple sclerosis (MS) patients. PBMCs were isolated from MS patients (RR, n = 25; SP, n = 25; and PP, n = 10) and controls (C, n = 15). HSF-1 gene expression was determined by real-time reverse transcriptase-polymerase chain reaction in PBMCs. The correlation between HSF-1 and MS disability was determined by Spearman correlation analysis. Patients with remitting-relapsing MS (RRMS) displayed higher HSF-1 expression (P = 0.043). No difference was observed among HSF-1 expression levels in other MS subtypes. HSF-1 expression was significantly correlated with Expanded Disability Status Scale (EDSS) scores in RRMS patients (P = 0.008), indicating a potential role of HSF-1 in MS disease
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