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Serum microRNA-126 and microRNA-378 levels are associated with the severity of heart failure after acute myocardial infarction.
MicroRNAs (miRNAs) are important non-coding RNAs, and are involved in the pathogenesis of heart failure (HF). miRNA-126 and miRNA-378 are expressed in endothelial cells, and both were previously found to be increased after myocardial infarction. The aim of the present study was to investigate the relation between plasma miRNA-126 and miRNA-378 levels and the severity of HF in patients with acute myocardial infarction (AMI). Patients included 82 (57 men; mean age 62 ± 14 years) with a first-ever AMI. HF was defined as Killip class ≥ 2 and left ventricular ejection fraction (LVEF) ≤ 45%. Left ventricular hypertrophy (LVH) was determined by echocardiography and defined as LV mass index ≥ 95 g/m(2.7) in men and ≥ 104 g/m(2.7) in women. In addition, LVEF was measured by echocardiography, LVH by echocardiography and LV ejection fraction by MRI. Next-generation sequencing was used to analyse plasma miRNAs. miRNA-126 and miRNA-378 levels were significantly increased in patients with HF compared to patients without HF (p = 0.003 and p The first picture you see is a picture of big, green, dollar bills. According to the New England American Bankers Association, the largest bill in the world is a $1,000,000 bill. It’s about five times the height
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