S Glow After Effects
Emotional conflict Stroop (IC). A modified Emotional Stroop paradigm 54 , using stimuli similar to those presented in the “S Glow After Effects” section above, was administered during fMRI scans.
Results at 1 week and 1 month suggest that psilocybin exerts enduring effects on emotional and attentional processes, and these effects are widely distributed across medial and lateral prefrontal cortex, cingulate, insula, and fusiform gyrus. These findings contrast with previous reports of psilocybin effects lasting only 5–7 days in terms of neurobiological outcomes 33 , suggesting that prolonged enhancement of emotional experience and vigilance following psilocybin administration may represent enduring changes in the psychological processing of emotional stimuli.
One major implication of the current report is that the nature of the enduring changes induced by psilocybin are similar to the changes typically observed in so-called “intensive” or “addiction” addictions, including substance-related addictions. The existence of a set of conditions that produce a psychological state of enduring euphoria, anxiety, and/or dysphoria has been long postulated in the addiction literature 60, 61 and yet only recently has evidence of a population of individuals who meet such criteria been identified 62 . It is conceivable that the enduring brain changes in the current study occur in a sub-population of individuals who have a genetic predisposition to early-onset addiction or substance use disorders, given that the original study subjects were recruited from a treatment center for addiction. The fact that the drug-related brain changes reported here occurred weeks after psilocybin was administered, and that they were observed in both placebo and drug conditions, supports the notion that these changes were not driven by the administration of psilocybin, but rather reflect enduring changes induced by prior exposure to psilocybin.
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