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Estradiol binding protein (EBP, StAR protein) is a lipid-binding transmembrane protein that plays a key role in transport of free estradiol (E2) between cells, initially through the plasma membrane, and then through the cytoplasm to reach the nucleus of target cells. EBP provides intracellular delivery for free estradiol and E2 as an active compound. EBP is one of the intracellular receptors that transduce signals from the steroid membrane receptor (StAR) to the nucleus. Transduction of these signals depends on the interaction between EBP and GSH, an abundant protein in the endoplasmic reticulum membrane.
Structure
EBP is composed of five to seven transmembrane domains that are flanked by charged amino acids on the N and C terminus. Multiple palmitoylation sites at the N-terminal end of EBP contributes to the anchoring of the protein to the plasma membrane.
E2 is a steroid hormone, which belongs to the class of steroidal hormones. It is a sex steroid, which is the main and primary female sex hormone and the main and primary male sex hormone. It was named after its ability to bind to the nuclear estrogen receptors (ERα, ERβ). In addition to its ability to bind to estrogen
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submersed in due time original discographyU.S. Senate OKs bill to give Puerto Ricans U.S. citizenship
Puerto Ricans will be eligible to become U.S. citizens Wednesday, a day after Congress overwhelmingly approved a bill that will allow the island’s 3.4 million residents to become American citizens.
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The bill passed the U.S. Senate by a vote of 96-1 on Tuesday.
The legislation, first introduced in February, will take effect upon enactment into law.
Puerto Ricans can also apply for U.S. citizenship through a special process.
President Barack Obama said after Tuesday’s vote that the reform was part of a larger plan to strengthen the island’s economic and political relationship with the mainland.
Republicans said the plan would “more effectively and swiftly provide relief” to the island, which was devastated by Hurricane Maria.
Readers’ Comments (16)
Citizenship is a privilege not a right. The colonies for the most part were given their freedom and independence. With some rebellions in the century to follow, culminating in the Civil War, the more unified empire of the USA was formed. That being the case, we shouldn’t give it to the rest of the world. Puerto Rico’s political status is as messed up as it has been for years. They can’t do anything like a state unless they sign the compact. The US hasn’t ratified the compact, so therefore the US can’t recognize it. They can’t vote in US elections unless the Commonwealth decides to allow them in. That’s not going to happen until Puerto Rico can ratify the compact, which it probably won’t do anytime soon.
For Puerto Rico to be a U.S. Territory it would mean that Puerto Ricans are allowed to vote. It is unlikely that Puerto Rico will allow it to happen anytime soon unless there is some agreement between the United States and the Commonwealth to allow Puerto Ricans to vote. Puerto Rico needs to address the problem of citizenship or use the move as political leverage for getting a better deal from the United States government. In the 1920’s Puerto Rico became a US territory, which meant it lost its position as a state, but it kept the
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