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Bug #67987 (getopt_long() fails on NULL and 0)
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Bile acids are synthesized from cholesterol in the liver and are excreted into the duodenum where they are reabsorbed and metabolized. Seven bile acids have been identified. Four of these (cholic acid, deoxycholic acid, chenodeoxycholic acid, and cholic acid glycine conjugate) occur in free and conjugated forms. All bile acids (except glycocholic acid) are sulfated. Primary conjugation occurs with glycine, taurine, or taurocholic acid in order of decreasing efficiency. This conjugation leads to a terminal 7 alpha-hydroxyl group in position C-7. Secondary conjugation can occur with steroid or phenol derivatives, but the exact pathways are not fully elucidated. Both conjugation steps are catalyzed by UDP-glucuronosyltransferases in the liver. The substrate specificities of these enzymes are very similar to those of the family of UDP-glucuronosyltransferases that have a broad substrate specificity, but that have been shown to be very specific for steroid hormones (i.e., glucuronidation can occur at C-6, C-16 and C-17 but cannot occur at C-7, C-18 or C-19). The process of bile acid conjugation is regulated in such a way that bile acid concentrations in the plasma or in the gallbladder should be kept at certain, specific levels. This regulation is achieved by the secretion of bile acids into the gut where these acids are reabsorbed and catabolized.
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